ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis.
BackgroundProtective responses against Mycobacterium tuberculosis are dependent on appropriate T cell and macrophage activation.Mycobacterial antigen six kDa early secreted antigenic target (ESAT6) and culture filtrate protein 10 (CFP10) can detect M.tuberculosis specific IFNgamma responses.However, most studies have been performed in non-endemic r